Four new tetramic acid and one new furanone derivatives from the plant endophytic fungus Neopestalotiopsis sp----中国科学院微生物研究所

科研成果

论文题目:	Four new tetramic acid and one new furanone derivatives from the plant endophytic fungus Neopestalotiopsis sp
作者:	Shasha Zhao, Shenxi Chen, Bo Wang, Shubin Niu, Wenping Wu, Liangdong Guo, and Yongsheng* Che.
联系作者:
刊物名称:	Fitoterapia
期:	103
卷:
页:	106-112
年份:	2015
影响因子:	2.466
论文下载:	http://www.sciencedirect.com/science/article/pii/S0367326X15000775
摘要:	Four new tetramic acid analogues neopestalotins A-D (1-4), one new furanone derivative neopestalotin E (6), and the known compound hymenosetin have been isolated from the solid cultures of the plant endophytic fungus Neopestalotiopsis sp. The structures of the new compounds were determined mainly by nuclear magnetic resonance (NMR) experiments. The absolute configurations of 1 and 2 were assigned by circular dichroism (CD) data, whereas those of 3 and 4 were deduced by a combination of CD and heteronuclear long range coupling (HETLOC) data. Compound 2 showed modest antimicrobial activity against the Gram-positive bacteria, Bacillus subtilis, Staphylococcus aureus col, and Streptococcus pneumoniae.