Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas----中国科学院微生物研究所

科研成果

论文题目:	Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas
作者:	Luan Chunguang Xie Lingling, Yang Xi, Miao Huifang, Lv Na, Zhang Ruifen, Xiao Xue, Hu Yongfei, Liu Yulan, Wu Na, Zhu Yuanmin, Zhu Baoli.
联系作者:
刊物名称:	Scientific Reports
期:	5
卷:
页:
年份:	2015
影响因子:	5.078
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摘要:	The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples from adenomas and adjacent tissues was characterized by deep sequencing. Ascomycota, Glomeromycota and Basidiomycota were identified as the dominant phyla in both adenomas and adjacent tissues from all subjects. Among the 60 genera identified, the opportunist pathogens Phoma and Candida represented an average of 45% of the fungal microbiota. When analyzed at the operational taxonomic unit (OTU) level, however, a decreased diversity in adenomas was observed, and three OTUs differed significantly from the adjacent tissues. Principal Component Analysis (PCA) revealed that the core OTUs formed separate clusters for advanced and non-advanced adenomas for which the abundance of four OTUs differed significantly. Moreover, the size of adenomas and the disease stage were closely related to changes in the fungal microbiota in subjects with adenomas. This study characterized the fungal microbiota profile of subjects with adenomas and identified potential diagnostic biomarkers closely related to different stages of adenomas.