| 论文题目: | Two Novel Reassortants of Avian Influenza A(H5N6) Virus in China |
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| 作者: | Bi Yuhai Mei Kun, Shi Weifeng, Liu Di, Yu Xiaolan, Gao Zhimin, Zhao Lihua, George F Gao, Chen Jianjun*, Chen Quanjiao*. |
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| 刊物名称: | J Gen Virol |
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| 年份: | 2015 |
| 影响因子: | 3.501 |
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| 摘要: | Eight avian influenza A(H5N6) viruses were isolated from live poultry markets (LPMs) in Sichuan and Jiangxi Provinces in 2014, including those close to the country where the human H5N6 infection occurred. Genetic and phylogenetic analyses revealed that these H5N6 viruses are novel reassortants between H5N1 clade 2.3.4 and H6N6 viruses, and have evolved into two distinct lineages (Sichuan and Jiangxi). Moreover, the human-H5N6 virus was closely related to the avian-source viruses of Sichuan lineage, Notably, H5N6 viruses contained a T160A substitution in the HA protein and an 11-amino acid-deletion in the NA stalk, which may aid in enhancing viral affinity for human-like receptors, and virulence in mammals. As the H5N1 virus infects humans through direct contact, infection with the novel H5N6 virus raises significant concerns that the H5 subtype is a likely candidate for a pandemic. Therefore, extensive and long-term surveillance of avian influenza viruses (AIVs) in LPMs is essential. |
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