Insights into battles between Mycobacterium tuberculosis and macrophages----中国科学院微生物研究所

科研成果

论文题目:	Insights into battles between Mycobacterium tuberculosis and macrophages
作者:	Xu Guanghua, Wang Jing, George Fu Gao, Liu Cui Hua
联系作者:	George Fu Gao, Liu Cui Hua
刊物名称:	Protein Cell
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年份:	2014
影响因子:	3.22
论文下载:	http://link.springer.com/article/10.1007%2Fs13238-014-0077-5
摘要:	As the first line of immune defense for Mycobacterium tuberculosis (Mtb), macrophages also provide a major habitat for Mtb to reside in the host for years. The battles between Mtb and macrophages have been constant since ancient times. Triggered upon Mtb infection, multiple cellular pathways in macrophages are activated to initiate a tailored immune response toward the invading pathogen and regulate the cellular fates of the host as well. Toll-like receptors (TLRs) expressed on macrophages can recognize pathogen-associated-molecular patterns (PAMPs) on Mtb and mediate the production of immune-regulatory cytokines such as tumor necrosis factor (TNF) and type I Interferons (IFNs). In addition, Vitamin D receptor (VDR) and Vitamin D-1-hydroxylase are up-regulated in Mtb-infected macrophages, by which Vitamin D participates in innate immune responses. The signaling pathways that involve TNF, type I IFNs and Vitamin D are inter-connected, which play critical roles in the regulation of necroptosis, apoptosis, and autophagy of the infected macrophages. This review article summarizes current knowledge about the interactions between Mtb and macrophages, focusing on cellular fates of the Mtb-infected macrophages and the regulatory molecules and cellular pathways involved in those processes.