| 论文题目: | Angucyclines as signals modulate the behaviors of Streptomyces coelicolor |
|---|---|
| 作者: | Wang Weishan#, Ji Junjie#, Li Xiao, Wang Juan, Li Shanshan, Pan Guohui, Fan Keqiang, Yang Keqian* |
| 联系作者: | Yang Keqian* |
| 刊物名称: | Proc Natl Acad Sci U S A |
| 期: | 111 |
| 卷: | 15 |
| 页: | 5688-93 |
| 年份: | 2014 |
| 影响因子: | 10.583 |
| 论文下载: | |
| 摘要: | The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has been found here to induce complex survival responses in Streptomyces coelicolor at subinhibitory concentration. The receptor for JdB was identified as a "pseudo" gamma-butyrolactone receptor, ScbR2, which was shown to bind two previously unidentified target promoters, those of redD (redDp) and adpA (adpAp), thus directly regulating undecylprodigiosin (Red) production and morphological differentiation, respectively. Because AdpA also directly regulates the expression of redD, ScbR2, AdpA, and RedD together form a feed-forward loop controlling both differentiation and Red production phenotypes. Different signal strengths (i.e., JdB concentrations) were shown to induce the two different phenotypes by modulating the relative transcription levels of adpA vs. redD. The induction of morphological differentiation and endogenous antibiotic production by exogenous antibiotic exemplifies an important survival strategy more sophisticated than the induction of antibiotic resistance. |
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