Two Sarcoviolins with Antioxidative and alpha-Glucosidase Inhibitory Activity from the Edible Mushroom Sarcodon leucopus Collected in Tibet----中国科学院微生物研究所

科研成果

论文题目:	Two Sarcoviolins with Antioxidative and alpha-Glucosidase Inhibitory Activity from the Edible Mushroom Sarcodon leucopus Collected in Tibet
作者:	Ma Ke, Han Junjie, Bao Li, Wei Tiezheng, Liu Hongwei*
联系作者:	Liu Hongwei*
刊物名称:	J Nat Prod
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年份:	2014
影响因子:	3.267
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摘要:	Edible mushrooms are known as an important source of natural antioxidants. The ethyl acetate extract of the edible mushroom Sarcodon leucopus (Zangzi mushroom) possesses strong antioxidative activity. Bioactivity-guided isolation afforded 10 compounds from its fruiting bodies, including two new sarcoviolins, sarcoviolin beta (1) and episarcoviolin beta (2), and one new p-terphenyl derivative (3) along with seven known compounds. The structures of the new compounds were elucidated by spectroscopic methods and comparison with the known compounds. Compounds 1-10 were found to have antioxidant effects in the DPPH scavenging assay, the total antioxidant capacity assay, the reducing power assay, and the lipid peroxidation assay. Further study indicated that they could protect DNA strands from free radical-induced cleavage at 200 muM. Compounds 1-10 also presented strong alpha-glucosidase inhibitory activity. Of all tested compounds, compound 1 exhibited the strongest inhibitory activity, with an IC50 value of 0.58 muM.