Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine----中国科学院微生物研究所

科研成果

论文题目:	Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine
作者:	Ju Ying#, Fan Hongxia#, Liu Jun, Hu Jun, Li Xinghui, Li Changfei, Chen Lizhao, Gao Qiang, George F Gao, Meng Songdong*
联系作者:	Meng Songdong*
刊物名称:	Vaccine
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年份:	2014
影响因子:	3.458
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摘要:	The commonly used inactivated or split influenza vaccines induce only induce minimal T cell responses and are less effective in preventing heterologous virus infection. Thus, developing cross-protective influenza vaccines against the spread of a new influenza virus is an important strategy against pandemic emergence. Here we demonstrated that immunization with heat shock protein gp96 as adjuvant led to a dramatic increased antigen-specific T cell response to a pandemic H1N1 split vaccine. Notably, gp96 elicited a cross-protective CD8+ T cell response to the internal conserved viral protein NP. Although the split pH1N1vaccine alone has low cross-protective efficiency, adding gp96 as an adjuvant effectively improved the cross-protection against challenge with a heterologous virus in mice. Our study reveals the novel property of gp96 in boosting the T cell response against conserved epitopes of influenza virus and its potential use as an adjuvant for human pre-pandemic inactivated influenza vaccines against different viral subtypes.