High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene----中国科学院微生物研究所

科研成果

论文题目:	High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene
作者:	Guo Guijie, Kang Qingzheng, Chen Qinghuang, Chen Zhilong, Wang Jun, Tan Li, Chen Ji-Long*
联系作者:	Chen Ji-Long*
刊物名称:	FEBS Lett
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年份:	2014
影响因子:	3.478
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摘要:	Dysregulation of non-coding RNA H19 has been observed in various tumors. However, it remains unknown whether H19 is involved in Bcr-Abl-induced leukemia. Here, we demonstrate a critical requirement for H19 in Bcr-Abl-mediated tumorigenesis. H19 was highly expressed in Bcr-Abl-transformed cell lines and primary cells derived from patients in a Bcr-Abl kinase-dependent manner. Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. These results reveal an important role H19 plays in Bcr-Abl-mediated transformation and provide novel insights into complex mechanisms underlying Bcr-Abl-induced cancers.