Cell Surface Vimentin is an Attachment Receptor for Enterovirus 71----中国科学院微生物研究所

科研成果

论文题目:	Cell Surface Vimentin is an Attachment Receptor for Enterovirus 71
作者:	Du Ning#, Cong Haolong#, Tian Hongchao, Zhang Hua, Zhang Wenliang, Song Lei, Tien Po*
联系作者:	Tien Po*
刊物名称:	J Virol
期:
卷:
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年份:	2014
影响因子:	4.893
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摘要:	Enterovirus 71 (EV71) is a highly transmissible pathogenic agent that causes severe central nervous system diseases in infected infants and young children. Here, we reported that EV71 VP1 protein could bind to vimentin intermediate filaments expressed on host cell surface. Soluble vimentin or an antibody against vimentin could inhibit the binding of EV71 to host cells. Accompanied with the reduction of vimentin expression on cell surface, the binding of EV71 to cells was remarkably decreased. Further evidence showed that the N terminal of vimentin is responsible for the interaction between EV71 and vimentin. These results indicated that vimentin on host cell surface may serve as an attachment site that mediated the initial binding and subsequently increased the infectivity of EV71. IMPORTANCE: This study delivers important findings on the roles of vimentin filaments in relation to EV71 infection and provides information that not only improved our understanding of EV71 pathogenesis, but also presents us with potentially new strategies for the treatment of diseases caused by EV71 infections.