Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii----中国科学院微生物研究所

科研成果

论文题目:	Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii
作者:	Chen Lin, Liu Yue-Tao, Song Bo, Zhang Hong-Wu, Ding Gang, Liu Xing-Zhong, Gu Yu-Cheng, Zou Zhong-Mei*
联系作者:	Chen Lin, Ding Gang, Zou Zhong-Mei*
刊物名称:	Fitoterapia
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年份:	2014
影响因子:	2.139
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摘要:	Three new cytochalasans, trichalasins E (1), F (2) and G (7), together with four known analogues, trichalasin C (3), aspochalasin K (4), trichalasin G (5) and aspergillin PZ (8), were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H. Chen. Trichalasins E (1) contains a unique hydroperoxyl group, which is the first report in all known analogues, whereas trichalasin G (7) possesses the rare 6/5/6/6/5 pentacyclic skeleton with 12-oxatricyclo [6.3.1.02,7] moiety as that of aspergillin PZ (8). The relative configurations of the new compounds were characterized by analysis of coupling constants and ROESY correlations, and the absolute configurations of trichalasins E (1), G (7) and aspergillin PZ (8) were determined by modified Mosher's reaction. In addition, compounds 1-5, 7 and 8 were tested cytotoxic activities against several cancer cell lines.