| 论文题目: | Distinct evolution process among type I interferon in mammals |
|---|---|
| 作者: | Xu Lei, Yang Limin*, Liu Wenjun* |
| 联系作者: | Yang Limin*, Liu Wenjun* |
| 刊物名称: | Protein & cell |
| 期: | 5 |
| 卷: | 4 |
| 页: | 383-92 |
| 年份: | 2013 |
| 影响因子: | 3.22 |
| 论文下载: | http://link.springer.com/article/10.1007%2Fs13238-013-3021-1 |
| 摘要: | Interferon (IFN) is thought to play an important role in the vertebrate immune system, but systemic knowledge of IFN evolution has yet to be elucidated. To evaluate the phylogenic distribution and evolutionary history of type I IFNs, 13genomes were searched using BLASTn program, and a phylogenetic tree of vertebrate type I IFNs was constructed. In the present study, an IFNdelta-like gene in the human genome was identified, refuting the concept that humans have no IFNdelta genes, and other mammalian IFN genes were also identified. In the phylogenetic tree, the mammalian IFNbeta, IFNvarepsilon, and IFNkappa formed a clade separate from the other mammalian type I IFNs, while piscine and avian IFNs formed distinct clades. Based on this phylogenetic analysis and the various characteristics of type I IFNs, the evolutionary history of type I IFNs was further evaluated. Our data indicate that an ancestral IFNalpha-like gene forms a core from which new IFNs divided during vertebrate evolution. In addition, the data suggest how the other type I IFNs evolved from IFNalpha and shaped the complex type I IFN system. The promoters of type I IFNs were conserved among different mammals, as well as their genic regions. However, the intergenic regions of type I IFN clusters were not conserved among different mammals, demonstrating a high selection pressure upon type I IFNs during their evolution. |
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