| 论文题目: | Placenta-derived gp96 as a multivalent prophylactic cancer vaccine |
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| 作者: | Zhao Bao, Wang Yanzhong, Wu Bo, Liu Shan, Wu Erjie, Fan HongXia, Gui MingMing, Chen Lizhao, Li Changfei, Ju Ying, Zhang Wei & Meng Songdong |
| 联系作者: | Meng Songdong |
| 刊物名称: | Scientific Reports 3 |
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| 年份: | 2013 |
| 影响因子: | 0 |
| 论文下载: | http://www.nature.com/srep/2013/130606/srep01947/full/srep01947.html#affil-auth |
| 摘要: | A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens. Given the striking similarity of antigen expression patterns between cancer and embryonic tissues, we defined a prototype strategy of using placenta-derived heat shock protein gp96, which induces prophylactic anti-tumor T cell responses. Immunization with placental gp96 provided partial protection and long-term (at least 3 months) anti-tumor immunity against growth of transplantable melanoma or breast tumors in mice, elicited total protection against 7, 12-dimethylbenz(a)-anthracene (DMBA)-induced mammary tumors in rats, and significantly reduced the occurrence and growth of autochthonous breast tumors in HER2 transgenic mice. Placental gp96 activated HER2- and MUC1-specific T cell responses through binding to tumor-associated antigens. Our results reveal the novel immunogenicity of placental gp96 and its potential use as a multivalent cancer vaccine. |
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