MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B----中国科学院微生物研究所

科研成果

论文题目:	MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B
作者:	Wang Saifeng, Zhang Xiaojun, Ju Ying, Zhao Bao, Yan Xiaoli, Hu Jun, Shi Lei, Yang Lebing, Ma Zhibo, Chen Lizhao, Liu Yali, Duan Zhongping, Chen Xinyue, Meng Songdong
联系作者:	Songdong Meng
刊物名称:	Journal of immunology
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年份:	2013
影响因子:	5.859
论文下载:	http://www.jimmunol.org/content/early/2013/05/21/jimmunol.1202100.long
摘要:	More than 350 million people are chronically infected with hepatitis B virus, and dysfunctional T cell responses contribute to persistent viral infection and immunopathogenesis in chronic hepatitis B (CHB). However, the underlying mechanisms of T cell hypo-responsiveness remain largely undefined. Given the important role of microRNA-146a (miR-146a) in diverse aspects of lymphocyte function, we investigated the potential role and mechanism of miR-146a in regulating T cell immune responses in CHB. We found that miR-146a expression in T cells is significantly up-regulated in CHB compared with healthy controls, and miR-146a levels were correlated with serum alanine amino transaminase levels. Both inflammatory cytokines and viral factors led to miR-146a up-regulation in T cells. Stat1 was identified as a miR-146a target that is involved in antiviral cytokine production and the cytotoxicity of CD4+and CD8+T cells. In vitro blockage of miR-146a in T cells in CHB greatly enhanced virus-specific T cell activity. Therefore, our work demonstrates that miR-146a up-regulation in CHB causes impaired T cell function, which may contribute to immune defects and immunopathogenesis during chronic viral infection.