| 论文题目: | Three antimycobacterial metabolites identified from a marine-derived Streptomyces sp. MS100061 |
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| 作者: | Chen Caixia, Wang Jian, Guo Hui, Hou Weiyuan, Yang Na, Ren Biao, Liu Mei, Dai Huanqin, Liu Xueting, Song Fuhang, Zhang Lixin |
| 联系作者: | Song Fuhang, Zhang Lixin |
| 刊物名称: | Applied microbiology and biotechnology |
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| 年份: | 2013 |
| 影响因子: | 3.613 |
| 论文下载: | |
| 摘要: | In the course of a screening program for bioactive compounds from a marine natural product library, a newly isolated Actinomycetes strain, designated as MS100061, exhibited strong anti-Mycobacterium bovis Bacillus Calmette-Guerin (BCG) activity. The strain belongs to the genus Streptomyces according to its morphological and 16S rDNA phylogenetic analysis. Bioassay-guided isolation resulted in a new spirotetronate, lobophorin G (1), together with two known compounds, lobophorins A (2) and B (3). The structures were elucidated by extensive spectroscopic methods and comparison with literatures. Compounds 1-3 were subjected to anti-BCG, antituberculosis, and antibacterial screening and exhibited potent anti-BCG activity with minimum inhibitory concentration (MIC) values of 1.56, 1.56, and 0.78 mug/ml, respectively, and moderate anti-Mycobacterium tuberculosis H37Rv activity with MIC values of 32, 32, and 16 mug/ml, respectively. The MIC values of compounds 1-3 against Bacillus subtilis were 3.125, 12.5, and 1.56 mug/ml, respectively, indicating great potential for antibacterial drugs. In addition, this is the first report of the anti-BCG and antituberculosis activities of lobophorins. |
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