An Airborne Transmissible Avian Influenza H5 Hemagglutinin Seen at the Atomic Level.----中国科学院微生物研究所

科研成果

论文题目:	An Airborne Transmissible Avian Influenza H5 Hemagglutinin Seen at the Atomic Level.
作者:	Zhang Wei, Shi Yi, Lu Xishan, Shu Yuelong, Qi Jianxun, George F. Gao
联系作者:	George F Gao
刊物名称:	Science
期:
卷:
页:	DOI: 10.1126/science.1236787
年份:	2013
影响因子:	32.452
论文下载:	http://www.sciencemag.org/content/early/2013/05/01/science.1236787.abstract?sid=2ec73b35-081e-4253-85e7-9a22672eab1c
摘要:	Recent studies have identified several mutations in the hemagglutinin (HA) protein that allow the highly pathogenic avian H5N1 influenza A virus to transmit between mammals by airborne route. Here, we determined the complex structures of wild-type and mutant HAs derived from an Indonesia H5N1 virus bound to either avian or human receptor sialic acid analogs. A cis/trans conformational change in the glycosidic linkage of the receptor analog was observed, which explains how the H5N1 virus alters its receptor binding preference. Furthermore, the mutant HA possessed low affinities for both avian and human receptors. Our findings provide a structural and biophysical basis for the H5N1 adaptation to acquire human, but maintain avian, receptor binding properties.