| 论文题目: | New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity |
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| 作者: | Chen, GD; Li, YJ; Gao, H; Chen, Y; Li, XX; Li, J; Guo, LD; Cen, YZ; Yao, XS |
| 联系作者: | Gao, H |
| 刊物名称: | PLANTA MEDICA |
| 期: | 15 |
| 卷: | 78 |
| 页: | 1683-1689 |
| 年份: | 2012 |
| 影响因子: | 2.153 |
| 论文下载: | |
| 摘要: | Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determined by detailed NMR and MS spectroscopic analyses. The absolute configurations of C-7 in chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3) were assigned by CD experiments, and the absolute configurations of 1 and 2 were established by X-ray crystallography. Compounds 1-3 are the first examples of 7R-configurated azaphilones with a chlorinated isochromen from Chaetomium spp. In addition, compounds 1-3 showed inhibitory activity in the cysteine aspartyl-specific protease-3 (caspase-3) enzymatic assay, with IC50 values of 20.6, 10.9, and 7.9 mu M, respectively. |
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