| 论文题目: | Brevianamides with Antitubercular Potential from a Marine-Derived Isolate of Aspergillus versicolor |
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| 作者: | Song, FH; Liu, XR; Guo, H; Ren, B; Chen, CX; Piggott, AM; Yu, K; Gao, H; Wang, Q; Liu, M; Liu, XT; Dai, HQ; Zhang, LX; Capon, RJ |
| 联系作者: | Zhang, LX |
| 刊物名称: | ORGANIC LETTERS |
| 期: | 18 |
| 卷: | 14 |
| 页: | 4770-4773 |
| 年份: | 2012 |
| 影响因子: | 5.862 |
| 论文下载: | |
| 摘要: | An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guerin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs. |
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