| 论文题目: | Quinazolin-4-one Coupled with Pyrrolidin-2-iminium Alkaloids from Marine-Derived Fungus Penicillium aurantiogriseum |
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| 作者: | Song, FH; Ren, BA; Yu, K; Chen, CX; Guo, H; Yang, N; Gao, H; Liu, XT; Liu, M; Tong, YJ; Dai, HQ; Bai, H; Wang, JD; Zhang, LX |
| 联系作者: | Zhang, LX |
| 刊物名称: | MARINE DRUGS |
| 期: | 6 |
| 卷: | 10 |
| 页: | 1297-1306 |
| 年份: | 2012 |
| 影响因子: | 3.854 |
| 论文下载: | |
| 摘要: | Three new alkaloids, including auranomides A and B (1 and 2), a new scaffold containing quinazolin-4-one substituted with a pyrrolidin-2-iminium moiety, and auranomide C (3), as well as two known metabolites auranthine (4) and aurantiomides C (5) were isolated from the marine-derived fungus Penicillium aurantiogriseum. The chemical structures of compounds 1-3 were elucidated by extensive spectroscopic methods, including IR, HRESIMS and 2D NMR spectroscopic analysis. The absolute configurations of compounds 1-3 were suggested from the perspective of a plausible biosynthesis pathway. Compounds 1-3 were subjected to antitumor and antimicrobial screening models. Auranomides A-C exhibited moderate cytotoxic activity against human tumor cells. Auranomides B was the most potent among them with an IC50 value of 0.097 mu mol/mL against HEPG2 cells. |
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