| 论文题目: | Molecular and antigenic characterization of H9N2 avian influenza virus isolates from chicken flocks between 1998 and 2007 in China |
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| 作者: | Zhang, Y; Yin, YB; Bi, YH; Wang, SC; Xu, SZ; Wang, JL; Zhou, S; Sun, TT; Yoon, KJ |
| 联系作者: | Yin, YB |
| 刊物名称: | VETERINARY MICROBIOLOGY |
| 期: | 40972 |
| 卷: | 156 |
| 页: | 285-293 |
| 年份: | 2012 |
| 影响因子: | 3.327 |
| 论文下载: | |
| 摘要: | Despite extensive vaccination, H9N2 subtype influenza A viruses have prevailed in chicken populations in China. H9N2 IAVs have been a major cause of respiratory disease and reduced egg production, resulting in great economic losses to the Chinese poultry industry. In attempt to find reasons for lack of adequate protection by commercial vaccines, 41 H9N2 viruses isolated from chicken flocks in various regions of China through surveillance between 1998 and 2007 were systemically analyzed using molecular and serological methods in comparison to IAV Ck/Shandong/6/96 and Ck/Shanghai/F/98 that have been used in a majority of commercial vaccines for H9N2 in China since 1998. The analyses showed that the field isolates were predominantly of Beijing/94 lineage and underwent rapid genetic and antigenic changes, forming several antigenic groups. Comparisons between the field isolates and vaccine strains revealed that a majority of the field isolates examined were antigenically distinct from the vaccine strains to some extent. Therefore, the rapid antigenic evolution of H9N2 IAV and resulting antigenic difference from the earlier vaccine strains appears to be a key factor for sub optimal control of H9N2 IAV in China, emphasizing that the vaccine strain should be updated in a timely manner through surveillance and accompanying laboratory evaluation of contemporary viruses for antigenic similarity with existing vaccine strains. (C) 2011 Elsevier B.V. All rights reserved. |
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