| 论文题目: | Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii |
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| 作者: | Ding, G; Wang, HL; Li, L; Chen, AJ; Chen, L; Chen, H; Zhang, HW; Liu, XZ; Zou, ZM |
| 联系作者: | Liu, XZ |
| 刊物名称: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY |
| 期: | 13 |
| 卷: | |
| 页: | 2516-2519 |
| 年份: | 2012 |
| 影响因子: | 3.329 |
| 论文下载: | |
| 摘要: | Two new cytochalasans, trichoderones A (1) and B (2), and three known analogues, aspochalasins D (3), J (4), and I (5), were isolated from the endophytic fungus Trichoderma gamsii. Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A (1) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B (2) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12-oxatricyclo [6.3.1.02,7] moiety. |
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