| 论文题目: | The complement C1qA enhances retinoic acid-inducible gene-I-mediated immune signalling |
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| 作者: | Wang, YT; Tong, XM; Zhang, JJ; Ye, X |
| 联系作者: | Ye, X |
| 刊物名称: | IMMUNOLOGY |
| 期: | 1 |
| 卷: | 136 |
| 页: | 78-85 |
| 年份: | 2012 |
| 影响因子: | 3.321 |
| 论文下载: | |
| 摘要: | The cellular innate immune response is essential for recognizing and defending against viral infection. Retinoic acid-inducible gene-I (RIG-I) and virus-induced signaling adaptor (VISA) mediated immune signalling is critically involved in RNA-virus-induced innate immune responses. Here we demonstrate that the complement C1qA interacts with different RIG-I pathway components and enhances RIG-I-VISA-mediated signalling pathway as well as TBK1-mediated activation of interferon-beta (IFN-beta) promoter. Our data show that over-expression of C1qA up-regulates RIG-I-mediated activation of IFN-stimulated responsive element (ISRE) and nuclear factor-?B reporters and IFN-beta transcription, but not IFN regulatory factor-3-mediated and inhibitor of ?B kinase-mediated activation of ISRE and nuclear factor-?B promoter. In addition, C1qA can counteract the function of the C1q receptor gC1qR in RIG-I-mediated signalling. Our results reveal the important role of complement C1qA in the innate immune response. |
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