| 论文题目: | Symphyocladins A-G: bromophenol adducts from a Chinese marine red alga, Symphyocladia latiuscula |
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| 作者: | Xu, XL; Piggott, AM; Yin, LY; Capon, RJ; Song, FH |
| 联系作者: | Capon, RJ |
| 刊物名称: | TETRAHEDRON LETTERS |
| 期: | 16 |
| 卷: | 53 |
| 页: | 2103-2106 |
| 年份: | 2012 |
| 影响因子: | 2.683 |
| 论文下载: | |
| 摘要: | Chemical analysis of a Chinese collection of the marine red alga Symphyocladia latiuscula yielded five unprecedented bromophenol-aconitic acid adducts, symphyocladins A-E, together with a new example of a bromophenol-pyroglutamic acid adduct, symphyocladin F, a new example of a bromophenol-urea adduct, symphyocladin G, and the known methyl ester of cis-aconitic acid. The structures were assigned on the basis of detailed spectroscopic analysis, and were consistent with a plausible biosynthetic pathway linking these bromophenol natural products with a putative quinone methide intermediate. Symphyocladins A/B and C/D were isolated as inseparable 1:1 mixtures of E/Z isomers. A plausible mechanism for their facile equilibration during handling and storage is presented. The bromophenol-urea exhibits antifungal activity (MIC 10 mu g/mL) against Candida albicans. (C) 2012 Elsevier Ltd. All rights reserved. |
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