| 论文题目: | Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii |
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| 作者: | Ding, G; Chen, L; Chen, A; Tian, XH; Chen, XD; Zhang, HW; Chen, H; Liu, XZ; Zhang, YG; Zou, ZM |
| 联系作者: | Zou, ZM |
| 刊物名称: | FITOTERAPIA |
| 期: | 3 |
| 卷: | 83 |
| 页: | 541-544 |
| 年份: | 2012 |
| 影响因子: | 1.848 |
| 论文下载: | |
| 摘要: | Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins 0(3). M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC50 value 5.72 mu M, whereas the EC50 values for compounds 1, 2 and 4, 5 are more than 40 mu M. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved. |
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