细菌对胞外ATP的反应机制

　　报告题目：细菌对胞外ATP的反应机制

　　报告人：吴建峰 博士

　　单位：美国密西根大学 公共健康学院 环境科学系

　　时间：2018年11月23 日 上午10：00

　　地点：微生物所A202会议室

　　主持人：姜成英 研究员

　　报告摘要：

　　Signaling by extracellular adenosine 5'-triphosphase (eATP) is very common for cell-to-cell communication in many basic patho-physiological development processes. Rapid release of ATP into the extracellular environment from distressed or injured eukaryotic cells due to pathogens or other etiological factors can serve as a "danger signal", activating host innate immunity. However, little is known about how or whether pathogenic bacteria respond to this "danger signal". Here we report that extracellular dATP/ATP can stimulate bacterial adhesion and biofilm formation via increased cell lysis and extracellular DNA (eDNA) release. We demonstrate that extracellular dATP/ATP also stimulates bacterial adherence in vitro to human bronchial epithelial cells. These data suggest that bacteria may sense extracellular dATP/ATP as a signal of "danger" and form biofilms to protect them from host innate immunity. This study reveals a very important and unrecognized phenomenon that both bacteria and host cells could respond to a common important signal molecule in a race to adapt to the presence of one another. We propose that extracellular dATP/ATP functions as an "inter-domain" warning signal that serves to induce protective measures in both Bacterial and Eukaryotic cells.

　　报告人简介：

　　吴建峰博士，1999年获安徽大学生命科学院微生物系学士学位，2002年获中科院南京土壤研究所微生物学专业硕士学位，2006年获中科院微生物研究所环境微生物博士学位，随后在美国密西根大学公共健康学院环境科学系历任博士后、研究科学员等职务。长期从事细菌生物膜研究，在小分子化合物抑制鲍曼不动杆菌形成生物膜的机理、一氧化氮对生物膜形成的抑制及其在医学临床上的运用、环境污染物对肠道菌群的构成和功能的影响及其对个体后续健康的影响、胞外DNA的特性及其在生物膜形成中的作用等方面取得了一系列成果，在微生物领域著名期刊如AEM, Archives of microbiology， Frontiers in microbiology，Environmental science and pollution research international等发表研究论文多篇，在细菌生物膜防控领域有深厚的研究积累。

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