Molecular mechanisms of biological sensing and response: the paradigm of bacterial chemotaxis

　　报告题目: Molecular mechanisms of biological sensing and response: the paradigm of bacterial chemotaxis

　　报 告 人: Prof. GERALD L. HAZELBAUER

　　报告人单位: University of Missouri-Columbia

　　报告时间: 2017年5月23日(星期二)15:30:00 ~ 16:30 pm

　　报告地点: A203会议室

　　主 持 人: 刘双江 研究员

　　报告摘要:

　　Life requires the ability to detect the environment and respond. Thus all cells have sensory systems. These systems recognize environmental change and couple recognition to cellular response. Central to most sensory systems are transmembrane receptors. These receptors detect the environment, transduce detection into informational signals that pass across the cellular membrane, and initiate intracellular signaling to mount an effective response. One of the most extensively characterized transmembrane sensory systems mediates bacterial chemotaxis. The system has become a paradigm for molecular characterization of biological signaling. This seminar will review the notably sophisticated molecular mechanisms and organization of the bacterial chemotaxis system, focusing on transmembrane chemoreceptors. It will outline recent progress in defining and understanding structure and functions of chemoreceptors and the chemotaxis core signaling complex, a transmembrane assembly of ten proteins. The outline will include descriptions of our laboratory’s utilization of Nanodisc technology for characterization of delicate transmembrane proteins like bacterial chemoreceptors that are fully active only if inserted in a lipid bilayer.

　　Background reading:

　　(1) Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Parkinson, J.S., Hazelbauer, G.L. and Falke, J.J. 2015. Trends in Microbiololgy 23: 257-266

　　(2) Bacterial chemoreceptors: providing enhanced features to two-component signaling. Hazelbauer, G.L. and Lai, W.-C. Curr. Opinion Microbiol. 2010:124-132

　　(3) Bacterial chemoreceptors: high-performance signaling in networked arrays. Hazelbauer, G.L., Falke, J.J., and Parkinson, J.S. 2008. Trends Biochem. Sci. 33, 9-19

　　报告人简介：

　　Prof. GERALD L. HAZELBAUER

　　Curators’ Distinguished Professor and Chair of Biochemistry at the University of Missouri-Columbia.

　　Education

　　B.A. 1966 Williams College, biology with honors

　　M.S. 1968 Case Western Reserve University, biology

　　Ph.D. 1971 University of Wisconsin, genetics (research with Julius Adler)

　　Professional Experience:

　　01/71 - 08/71 Postdoctoral researcher University of Wisconsin (Julius Adler)

　　09/71 - 08/73 Postdoctoral fellow Institut Pasteur, Paris (Jean-Pierre Changeux)

　　08/73 - 06/75 Research Associate Institute of Molecular Biology, U. of Uppsala, Sweden

　　07/75 - 12/80 Assistant Professor Institute of Molecular Biology, U. of Uppsala, Sweden

　　01/81 - 08/82 Associate Scientist Biochemistry and Biophysics, Washington State U.

　　09/82 - 08/85 Associate Professor Biochemistry and Biophysics, Washington State U.

　　09/85 - 09/00 Professor, Biochemistry and Biophysics, Washington State U.

　　08/94 - 08/99 Chair Biochemistry and Biophysics, Washington State U.

　　10/00 - Professor and Chair, Dept of Biochemistry, University of Missouri-Columbia

　　10/12- University of Missouri Curators’ Distinguished Professor

　　欢迎科研人员和研究生朋友踊跃参加!