Pneumococcal biofilm colonization, transformation, and transition to disease: Mechanisms and implications for therapeutic intervention

发布时间: 2017-04-25 来源:

  报告题目:Pneumococcal biofilm colonization, transformation, and transition to disease: Mechanisms and implications for therapeutic intervention

  报告人:Anders P. Hakansson

  报告人单位:Wallenberg Laboratory, Division of Experimental Infection Medicine,Department of Translational Medicine, Lund University, Malm?, Sweden


  报告地点:微生物所C404 会议室

  主持人:冯婕 项目研究员


  Streptococcus pneumoniae is an excellent colonizer of the human nasopharynx. It colonizes though the formation of bacterial biofilms, structured microbial communities enclosed in bacterially produced matrix with incorporation of host components. During colonization in biofilms, down-regulate capsule and up-regulate competence to easily transfer genetic information. This is the main niche where genetic exchange is thought to occur. Upon changes of the nasopharyngeal environment caused by virus infection or other stimuli associated with inflammation, bacteria in biofilms with sense and respond to these threatening changes by changing their transcriptome dramatically and actively releasing themselves from biofilms to spread to other hosts or disseminate to other sites, such as the middle ear and lungs, where they will cause highly inflammatory disease. By exploiting the bacterial changes occurring as the bacteria transition from silent biofilm bacteria to aggressive disseminating bacteria, we have been able to devise disease-specific vaccines that will not affect the delicate balance of the microbiome in the nasopharynx.


  Anders P. Hakansson教授在瑞典Lund University获得微生物学博士学位,博士后在美国的阿拉巴马大学及位于波士顿的Brigham and Women’sHospital、Children’s Hospital,现分别担任美国纽约州立大学布法罗分校微生物与免疫专业助教及瑞典Lund University转化医学专业终身教授,在PNAS、MBio、Mol. Microbiol、Cell Microbiol、 Anesthesiology等专业期刊发表论文100余篇,申请专利5项。

  Key Publications :

  Reddinger R M, Lukemarshall N R, Hakansson A P, et al. Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease[J]. Mbio, 2016, 7(4).

  Li Y, Hill A, Beitelshees M, Hakansson A P,et al. Directed vaccination against pneumococcal disease.[J]. Proc. Natl. Acad. Sci. USA 2016, 113(25): 6898-6903.

  Jones C H, Ravikrishnan A, Chen M, Hakansson A P, et al. Hybrid biosynthetic gene therapy vector development and dual engineering capacity[J]. Proc. Natl. Acad. Sci. USA, 2014, 111(34): 12360-12365.