Wgs-aqua.net:molecular epidemiology of aquaculture pathogens using whole genome sequencing

　　报告题目：Wgs-aqua.net: molecular epidemiology of aquaculture pathogens using whole genome sequencing

　　报告人：Professor Edward Feil

　　报告人单位：Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK

　　报告时间：2016年10月24日(周一)上午9:30？11:00

　　报告地点：微生物所A203 会议室

　　主持人：冯婕 副研究员

　　Introduction：

　　Professor Edward Feil’s interests lie in using sequence data to study bacterial pathogens, both from a point of view of managing infections (molecular epidemiology) but also in terms of understanding fundamental evolutionary dynamics. The early part of his research career was spent generating and interpreting multilocus sequence typing (MLST) data for numerous species. He developed the BURST algorithm to help visualise these datasets.

　　More recently, he has focussed on whole genome sequence (WGS) data, and was joint lead author on the first demonstration of WGS data for molecular epidemiology. He is currently a PI on a large CRCUK project, headed by Prof Sharon Peacock, looking at implementing this technology into routine epidemiological surveillance, and was previously a work package leader on the FP7 Project TROCAR, headed by Prof Jordi Villa, which aimed to characterise and manage high risk antibiotic resistant clones in Europe.

　　He also has a strong interest in using WGS to understand and manage the spread of bacterial pathogens in animals. He was a PI on consortium funded under the insect pollinator initiative looking at the epidemiology of European Foul Brood in honeybees, and am currently PI on the BBSRC/NERC funded project wgs-aqua.net, which aims to deploy WGS to manage bacterial pathogens of aquaculture (in collaboration with Cefas, Weymouth, the University of Stirling and the Centre for Genomic Pathogen Surveillance, Wellcome Trust Sanger Institute).

　　In addition to molecular epidemiology, WGS data of bacterial pathogens can shed light on basic evolutionary questions concerning diversification; mutation, recombination and selection. Research questions include the strength of selection on intergenic sites, codon bias, context dependant mutation, the maintenance of GC content, INDEL formation, and gene essentiality.

　　He was awarded the Zoological Society of London Scientific Medal in 2010, and is an ISI highly cited researcher for 2015.

　　Key Publications

　　2016. Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland. Genome Research.

　　2016. Whole-genome sequencing for routine pathogen surveillance in Public Health: a population snapshot of invasive staphylococcus aureusin Europe. mBio.

　　2015. Alternative splice in alternative lice. Molecular Biology and Evolution.

　　2014. Molecular epidemiology and population structure of the honey bee brood pathogen Melissococcus plutonius. ISME Journal.

　　2012. The emergence and spread of dysentery. Nature Genetics.

　　2010. Evolution of MRSA during hospital transmission and intercontinental spread. Science.

　　For full listing http://www.bath.ac.uk/bio-sci/contacts/academics/ed_feil/