|
组长：刘宁宁 博士、研究员 |
|
研究队伍 研究组长：刘宁宁 研究员 博士生导师 电子邮件：liunn#im.ac.cn(#替换成@) 通讯地址：北京市朝阳区北辰西路1号院3号 邮编：100101
|
|
研究方向 慢性感染的免疫微环境及糖脂代谢调控机制
|
|
研究内容及意义
炎癌转化及肝癌免疫微环境调控 脂肪性肝炎的糖脂代谢调控 移位感染的免疫调控-肠肝轴/肺肝轴 通过临床患者样本分析并结合小鼠肝脏疾病模型，利用单细胞转录组测序技术，基因编辑体内筛选系统，免疫细胞图谱分析以及代谢组学分析等前沿技术探究免疫微环境和糖脂代谢的调控机制，揭示肝脏慢性病及肝癌的潜在治疗靶点，探索治疗策略。
|
|
主要学习及工作经历
2011-2014 中国科学院大学，博士 2014-2017 中国科学院微生物研究所，助理研究员 2017-2021 美国明尼苏达大学，博士后 2021-2022 美国西南医学中心，讲师 2022年11月-至今 中国科学院微生物研究所 研究员，博士生导师
|
|
代表性论文 1. Dandan Qi, Min Lu, Pengfei Xu, Xinli Yao, Yongchen Chen, Lipeng Gan, Yong Li, Yahua Cui, Xiaomei Tong, Shuhong Liu, Jingmin Zhao#,Ningning Liu#, Xin Ye#. Transcription Factor ETV4 Promotesthe Development of Hepatocellular Carcinoma by Driving Hepatic TNF- Signaling.Cancer Communications, 2023.#co-corresponding author. 2. Ningning Liu*, Jing Tian*, Clifford J. Steer, Qinghua Han#and Guisheng Song#. MicroRNA-206-3p Suppresses Hepatic Lipogenesis and cholesterol synthesis while driving cholesterol efflux.Hepatology,2023.*co-first author. 3. Ningning Liu, Clifford J. Steer, and Guisheng Song. MicroRNA-15a/16-1 Prevent Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Regulatory T Cells.Gastroenterology, 2022. 4. Ningning Liu, Xiaomei Wang, Clifford J. Steer, and Guisheng Song. MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Phase Polarization of Kupffer Cells.Gut, 2022. 5. Ningning Liu, Clifford J Steer, Guisheng Song. MicroRNA-206 Enhances Antitumor Immunity by Disrupting the Communication between Malignant Hepatocytes and Tregs in c-Myc Mice.Hepatology, 2022. 6. Ningning Liu*, Tianpeng Zhang*, Clifford J Steer, Guisheng Song. MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis.Cell & Bioscience, 2022. *co-first author. 7. Ningning Liu*, Qi Liu*, Xiaohai Yang*, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, and Xin Ye. Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity.Hepatology, 2018. *co-first author. 8. Ningning Liu*, Jinfang Zhang*, Xiaohai Yang, Tong Jiao, Xin Zhao, Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li, and Xin Ye. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx to Enhance its Stability and Function.Journal of Virology, 2017. *co-first author. 9. Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, and Xin Ye. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway.Journal of Virology, 2015. 10. Ningning Liu, Jinfang Zhang, Tong Jiao, Zhiwei Li, and Xin Ye. Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA-15a/16 Cluster.Journal of Virology, 2013. |
|
研究中代表性图片
|
