分子病毒与生物制药研究组

工作人员 

孙 蕾 博士 副研究员                 Lei Sun  Ph.D., Associate professor 

杨利敏 博士在读 副研究员             Limin Yang MS, Associate professor 

李 晶 博士 副研究员                 Jing Li Ph.D., Associate professor 

范文辉 博士 助理研究员               Wenhui Fan Ph.D., Research Assistant 

李云龙 研究助理                       Yunlong Li  Research Assistant 

祝荣格 研究助理                       Rongge Zhu Research Assistant 

梁希   研究助理                       Xi Liang    Research Assistant 

张鹤   研究助理                       He Zhang    Research Assistant 

魏艳秋 研究助理                       Yanqiu Wei   Research Assistant 

   王  选   研究助理                       Xuan Wang  Research Assistant 

博士研究生 

崔亮2014-2016                           Liang/Cui 2014-2016 

杨文贤2015-2017                         Wenxian/Yang 2015-2017 

石金超2015-2017                         Jinchao/Shi 2015-2017 

白晓园2017-2020                         Xiaoyuan/Bai 2017-2020 

焦鹏涛2017-2020                         Pengtao/Jiao 2017-2020 

闵洁2017-2021                           Jie/Min 2017-2021 

硕士研究生 

马迪娜·马合苏提汗2015-2017            Madina/Ma  2015-2017 

刘丽蓉2016-2019                        Lirong/Liu  2016-2019 

王萌2017-2020                          Meng/Wang 2017-2020 

田璐2017-2020                          Lu/Tian 2017-2020 

田晓东2017-2020                        Xiaodong/Tian 2017-2020 

李明慧2017-2020                        Minghui/Li 2017-2020 

刘杨2017-2020                          Yang/Liu 2017-2020 

代表文章（近10年）： 

1. W-J Chai#, J Li#, Q Shangguan, Q Liu, X-D Li, D-D Qi, X-M Tong, W-J Liu, X Ye*. 2018. Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression.Journal of Virology.doi: doi:10.1128/JVI.00539-18 

2. J Li,K Zhang, Q-Y Chen, X Zhang, Y-P Sun, Y-H Bi, S Zhang, J-Y Gu, J-R Li, Di Liu,W-J Liu*, J-Y Zhou*.2018.Three Amino Acid Substitutions in the NS1 Protein change the Virus Replication of H5N1 Influenza Virus in Human Cells.Virology. doi: 10.1016/j.virol.2018.04.004 

3. Y Li, L Sun*, W-N Zheng, Madina·M, J Li, Y-H Bi, H Wang, W-J Liu*, Luo T*. 2018. Phosphorylation and dephosphorylation of threonine 188 innucleoprotein is crucial for the replication of influenza A virus.Virology. doi: 10.1016/j.virol.2018.05.002 

4. C Chen, W-H Fan, J Li, W-N Zheng, S Zhang, L-Y Yang, D Liu, W-J Liu*, L Sun*.2018. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus.Front. Cell. Infect. Microbiol. 8:127. doi.org/10.3389/fcimb.2018.00127 

5. Y-P Sun,J-W Jiang, P Tien, W-J Liu*,J Li*. 2018. IFN-λ: A new spotlight in innate immunity against influenza virus infection.Protein & Cell.doi: 10.1007/s13238-017-0503-6 

6. Y-P Sun,J Li^*, P Tien,George Fu Gao, W-J Liu*. 2018.Bunyavirales Ribonucleoproteins: the Viral Replication and Transcription Machinery.Critical Reviews in Microbiology.doi: 10.1080/1040841X.2018.1446901 

7. J Li, JLu, S Zhang,WangJ, FLiu,M Fang, X-F Duan*, W-J Liu. 2018. Differential Immune Response of Influenza A Virus-infected Dendritic Cells and Association with Autophagy.Future Virology.10.2217/fvl-2017-0044. 

8. W Liu#, J Li#, W-N Zheng, Y-L Shang, Z-D Zhao, S-S Wang, Y-H Bi, S Zhang, C-F Xu, Z-Y Duan, L-F Zhang, Y Wang, Z-F Jiang, W-J Liu*, L Sun*. 2017. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife, 6(8); 6. pii: e24425 

9. J L#i, W-N Zheng#, L-D Hou#, C Chen, W-H Fan, H-R Qu, J-W Jiang, J Liu,George Fu Gao, J-Y Zhou, L Sun*, W-J Liu*. 2016. Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism.Cellular Microbiology. doi: 10.1111/cmi.12692 

10.W-N Zheng#, S-S Cao#, C Chen#, J Li, Sh Zhang, J-W Jiang, Y-G Niu, W-H Fan, Y Li, Y-H Bi, George Fu Gao, L Sun*, W-J Liu*. 2016. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.Cellular Microbiology. doi:10.1111/cmi.12643. 

11. J Li, C Chen, Gary W, W Dong, W-N Zheng, Y Li, L Sun, L-F Zhang,George Fu Gao, Y-H Bi, W-J Liu*. 2016. Cyclophilin A protects mice against infection by influenza A virus.Scientific reports28978. 

12. J-W Jiang, J Li*, W-H Fan, W-N Zheng, M Yu, C Chen, L Sun, Y-H Bi, C Ding,George Fu Gao, W-J Liu*. 2016. Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.Journal of Virology.pii: JVI.00549-16. 

13. Y-G Niu, Y Liu, L-M Yang, H-R Qu, J Zhao, R-L Hu, J Li*, W-J Liu*. 2016. Evaluation of the immunogenicity of multi-epitope-based vaccine candidates against rabies adjuvant with Gp96.Virologica Sinica, 4; 31(2):168-75. 

14. J Li, Y-H Rao, Q-L Sun, X-X Wu, J Jin, Y-H Bi, J Chen, F-M Lei, Q-Y Liu, Z-Y Duan, J-C Ma, George Fu Gao, D Liu, W-J Liu*. 2015. Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China.Scientific reports, 18094, doi: 10.1038/srep18094 

15. J Li, W-J Liu*. 2015. Diversity of the RNA polymerase in the H7N9 Influenza A Virus.Advances in Microbiology, 5: 661-667 

16.  J Li, T Qin, X-X Jia, A-H Deng, X Zang, W-H Fan, S-D Huo, T-Y Wen, W-J Liu*. 2015. Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy.Biomedical and Environmental Sciences, 2015; 28(6): 77-84 

17.  X-J Jia, Y-H Bi, J Li, Q Xie, H-C Yang*, W-J Liu*.2015. Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity,Scientific reports, 10651 

18.  K Zhang#, Z Wang#, G-Z Fan, J Wang, S-Y Gao, Y Li, L Sun, C-C Yin*, W-J Liu*. 2015.Two Polar Residues Within C-terminal Domain of M1 are Critical for the Formation of Influenza A Virus Matrix Layer,Cellular Microbiology(10)1111/cmi.12457 

19.  J Li, M Yu, W-N Zheng, W-J Liu*. 2015.Nucleocytoplasmic Shuttling of Influenza A Virus Proteins,Viruses7, 2668-2682. 

20.  W-N Zheng, J Li, S-S Wang, S Cao, J-W Jiang, C Chen, C Ding, C Qin, X Ye, George Fu Gao, W-J Liu*. 2015. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein.Journal of Virology. 3(18).pii: JVI.00015-15. 

21.  Y-H Bi, Q Xie, S Zhang, Y Li, H-X Xiao, T Jing, WN Zheng, J Li, X-J Jia, L Sun, J-H Liu, C Qin, George F Gao, W-J Liu*. 2014. Assessment of the internal genes of influenza A (H7N9) virus contributing to the high pathogenicity in mice.Journal of Virology. doi:10.1128/JVI.02390-14 

22.  Y-H Bi, J Li, L-M Yang, S Zhang, Y Li, X-J Jia, L Sun, Y-B Yin, C Qin, B-N Wang, George Fu Gao, W-J Liu*. 2014. Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae.Vet Microbiol, doi:10.1016/j.vetmic.2014.08.010 

23.  Sh Cao#, J-W Jiang#, J Li, Y Li, L-M Yang, Sh-Sh Wang, J-H Yan, George F Gao, W-J Liu*. 2014. Characterization of The Nucleocytoplasmic Shuttle of The Matrix Protein of Influenza B Virus.Journal of Virology.88 (13):7464-7473 

24.  Sh-Y Gao, Sh-Sh Wang, Sh Cao, L Sun, J Li, Y-H Bi, George F Gao, W-J Liu*. 2014. The characteristics of nucleocytoplasmic transport of H1N1 influenza A viruses nuclear export protein (NEP).Journal of Virology. 88 (13):7455-7463 

25.  L Xu, L-M Yang,W-J Liu*.2013.Distinct evolution process among type I interferon in mammals.Protein Cell.May;4(5):383-92 

26.  S-S Wang, Zh-D Zhao, Y-H Bi, L Sun, X-L Liu*, W-J Liu*.2013.Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling its nuclear import.Journal of Virology,87(11):6182-91 

27.  J Li, Y-H Bi, C Chen, L-M Yang, W-J Liu*.2013. Genetic characterization of Duck Hepatitis A Viruses isolated in China.Virus Research.(doi:10.1016/j.virusres.2013.10.007) 

28.  X-L Liu, Zh-D Zhao, W-J Liu*.2013.Insights into the Roles of Cyclophilin A during Influenza Virus Infection.Viruses. 5:182-191 

29.  L-M Yang,J-Y Cen, Q-H Xue, J Li, Y-H Bi, L Sun, W-J Liu*.2013. Identification of Rabies Virus Mimotopes Screened from a Phage Display Peptide Library with Purified Dog Anti-Rabies Virus Serum IgG..Virus Research. 174:47-51 

30.  H-R Qv#, L-M Yang#, S-S Meng,L Xu, Y-H Bi, X-J Jia, J Li, L Sun, W-J Liu*.2013.The Differential Antiviral Activities of Chicken Interferon α (ChIFN-α) and ChIFN-β Are Related to Distinct Interferon-stimulated Gene Expression,PLoS One. (doi: 10.1371/journal.pone.0059307) 

31.  C-W Chen, J Li, Y-H Bi, L-M Yang, S-S Meng, Y-C Zhou, X-J Jia, S-D Meng, L Sun, W-J Liu*.2013. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity,Vaccine. (doi: http://dx.doi.org/10.1016/j.vaccine.2013.01.049) 

32.  C-W Chen, W-H Fan, X-J Jia, J Li, Y-H Bi, W-J Liu*2013.Development of a recombinant N-Gp5c fusion protein-based ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus.J Virol Methods. 4:189(1):213-20 

33.  Sh Cao, Yi Shi, Sh-G Tan, H Song, George F. Gao*, W-J Liu*. 2012. Reply to "Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1"--Sequence Sharing Between Viral Nuclear Export Signals (NES) and CD8+ T Cell Epitopes.Journal of Virology, 86(18):10259-10260 

34.  M-R Yu#, X-L Liu#, Sh Cao, Zh-D Zhao, K Zhang, Q Xie, C-W Chen, Sh-Y Gao, Y-H Bi, L Sun, X Ye, George F. Gao, W-J Liu*. 2012.Identification and Characterization of three novel nuclear export signals in influenza A virus nucleoprotein.Journal of Virology, 86(9):4970-80 

35.  Sh Cao, X-L Liu, M-R Yu, J Li, X-J Jia, Y-H Bi, L Sun, George F. Gao, W-J Liu*. 2012.A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for the Efficient Virus Replication.Journal of Virology,86(9):4883-91 

36.  X-L Liu#, Zh-D Zhao#, Zh Li, Ch-F Xu, L Sun, J-L Chen, W-J Liu* 2012. Cyclosporin A inhibits the Influenza Virus Replication through cyclophilin A-dependent and -independent pathways.PLoS ONE,7(5):e37277 

37.  K Zhang, Zh Wang, X-L Liu, Ch-ch Yin, Basit Zeshan, B Xia^*, W-J Liu*. 2012. Dissection of Influenza A Virus M1 Protein: pH-Dependent Oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain.PLoS ONE,7(5): e37786. 

38.  X-L Liu#, Zh-D Zhao#, Ch-F Xu, L Sun, J-L Chen, L-F Zhang, W-J Liu*. 2012. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein.PLoS ONE, 7(2): e31063. 

39.  C-W Chen, J Li, Y-H Bi, X-J Jia, S-D Meng, L Sun, W-J Liu*. 2012.Gp96 enhances the immunogenicity of subunit 1 vaccine of Porcine reproductive and 2 respiratory syndrome virus.Virus Research, 167(2):162-72. 

40.  Y-L Wang,J Li, Y-H Bi, L Xu, W-J Liu*. 2012.Development and application of a reverse transcription loop-mediated isothermal amplification method for rapid detection of Duck hepatitis A virus type 1. Virus Genes, doi 10.1007/s11262-012-0798-6 

41.  Z-F Wang, X-L Liu, Z-D Zhao, C-F Xu, K Zhang, C-W Chen, L Sun, F Gao, X Ye, W-J Liu*, 2011, Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the ribonucleoprotein complex.PLoS ONE6(8): e22625. doi:10.1371/journal.pone.0022625 

42.  S-S Meng, L-M Yang, C-F Xu, Z-M Qin, H-Y Xu, Y-L Wang,L Sun and W-J Liu*.Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replicationin vivoby Oral Administration.Journal of Interferon and Cytokine Research.2011, 7; 31(7):533-8 

43.  Y-H Bi^#, L Lu^#, J Li, Y-B Yin, Y Zhang, H-J Gao, Zh-M Qin, Basit Zeshan, J-H Liu, W-J Liu*, L Sun*. Novel genetic reassortants in H9N2 influenza A Viruses and the diverse pathogenicity to mice.Virology Journal, 2011, 8:505 

44.  L Lu, Y-B Yin, Z-S Sun, L Gao,F Gao, S-D Liu, L Sun*andW-J Liu*. 2010. Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology. 49(3): 186-91. 

45.  M-R Yu, X-L Liu, L Sun, C-W Chen, G-P Ma, Y. Kitamura, F Gao and W-J Liu*.2010.Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein.Virus Research. 152(1-2): 104-14. 

46.  C-F Xu, S-S Meng, X-L Liu,L Sun and W-J Liu*.2010. Chicken Cyclophilin A is an inhibitory factor to influenza virus replication. Virology Journal.7(1): 372. 

47.  Q-H Xue, L-M Yang, X-L Liu and W-J Liu*. 2010. Molecular characterization of feline interferon receptor 2.Journal of Interferon and Cytokine Research. 30(2): 81-8. 

48.  L Sun, G-H Zhang, Y-L Shu, X-M Chen, Y-P Zhu, L-M Yang, G-P Ma, Y.Kitamura and W-J Liu*. 2009. Genetic correlation between H3N2 human and swine influenza viruses.Journal of Clinical Virology. 44(2): 141-4. 

49.  X-L Liu, L Sun, M-R Yu, Z-F Wang, C-F Xu, Q-H Xue, K Zhang, X Ye, Y. Kitamura and W-J Liu*. 2009. Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication.Cellular Microbiology. 11(5): 730-41. 

50.  J-J Zhang, G Li, X-L Liu, Z-F Wang, W-J Liu* and X Ye*. 2009.Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA.Journal of General Virology.90(11): 2751-8. 

51.  D Liu, X-L Liu, J-H Yan, W-J Liu* and F. Gao*. 2009. Interspecies transmission and host restriction of avian H5N1 influenza virus. Science in China Series C:Life Science. 52(5): 428–38.